Principal Investigator
Sara Buhrlage, PhD
Sara joined the DFCI Cancer Biology and HMS Biomolecular and Cellular Pharmacology faculty in 2015. Prior to making the move to an academic position Sara was a professional track scientist in Dana-Farber's medicinal chemistry core laboratory. In that role she collaborated with cancer biologists and clinicians to pharmacologically validate novel targets of disease in vitro and in vivo and to study mechanisms of disease and drug resistance. Sara received her PhD in organic chemistry from University of Michigan in 2008 under the direction of Professor Anna Mapp then trained for two years in medicinal chemistry at the Broad Institute before moving to DFCI. In addition to pursuing novel strategies for challenging drug targets Sara enjoys playing soccer, cooking and spending time with her husband and daughter.
Sara joined the DFCI Cancer Biology and HMS Biomolecular and Cellular Pharmacology faculty in 2015. Prior to making the move to an academic position Sara was a professional track scientist in Dana-Farber's medicinal chemistry core laboratory. In that role she collaborated with cancer biologists and clinicians to pharmacologically validate novel targets of disease in vitro and in vivo and to study mechanisms of disease and drug resistance. Sara received her PhD in organic chemistry from University of Michigan in 2008 under the direction of Professor Anna Mapp then trained for two years in medicinal chemistry at the Broad Institute before moving to DFCI. In addition to pursuing novel strategies for challenging drug targets Sara enjoys playing soccer, cooking and spending time with her husband and daughter.
Staff Scientist
Xiaoxi Liu, PhD
Dr. Xiaoxi Liu focuses on medicinal chemistry optimization of small molecules targeting deubiquitinating enzymes. He joined the group in January of 2016. He brings to the group extensive experience in synthetic organic chemistry, natural product total synthetic, heterocyclic chemistry and pharmaceuticals. Prior to joining the group Dr. Liu was a postdoctoral researcher in the Department of Chemistry at the University of Vermont for 1 year where his research centered on conceptually novel chirality-assisted synthesis of enantiomerically pure macromolecules. Dr. Liu obtained his doctoral degree in organic chemistry from UVM as well. His graduate research focused on the total synthesis of medicinally relevant natural products as well as contributions to methodology for heterocycle synthesis. He has presented his work at invited lectures and national conferences and has authored high-impact peer-reviewed articles. In his spare time, he enjoys cooking, running and playing soccer, as well as spending time with his wife and son.
Dr. Xiaoxi Liu focuses on medicinal chemistry optimization of small molecules targeting deubiquitinating enzymes. He joined the group in January of 2016. He brings to the group extensive experience in synthetic organic chemistry, natural product total synthetic, heterocyclic chemistry and pharmaceuticals. Prior to joining the group Dr. Liu was a postdoctoral researcher in the Department of Chemistry at the University of Vermont for 1 year where his research centered on conceptually novel chirality-assisted synthesis of enantiomerically pure macromolecules. Dr. Liu obtained his doctoral degree in organic chemistry from UVM as well. His graduate research focused on the total synthesis of medicinally relevant natural products as well as contributions to methodology for heterocycle synthesis. He has presented his work at invited lectures and national conferences and has authored high-impact peer-reviewed articles. In his spare time, he enjoys cooking, running and playing soccer, as well as spending time with his wife and son.
Post-Doctoral Fellows
Jing Yang, PhD
Jing grew up in the middle part of China and received her B.S. degree in Microbiology there. She then graduated from the Chinese Academy of Sciences with a Ph.D in Molecular Immunology in 2015. She joined the Buhrlage Lab as a research fellow with the goal of training in cancer biology and identifying new therapeutic targets. In her free time she enjoys cooking, reading, writing and spending time with her family and friends.
Jing grew up in the middle part of China and received her B.S. degree in Microbiology there. She then graduated from the Chinese Academy of Sciences with a Ph.D in Molecular Immunology in 2015. She joined the Buhrlage Lab as a research fellow with the goal of training in cancer biology and identifying new therapeutic targets. In her free time she enjoys cooking, reading, writing and spending time with her family and friends.
Rob Magin, PhD
Rob Magin is originally from Silver Spring, MD. He obtained his BA in biology from Northwestern University in 2012 and his PhD from the University of Pennsylvania in biochemistry and molecular biophysics in 2017. He joined the Buhrlage lab as a postdoctoral research fellow in the Fall of 2017. His research interests include chemical biology, structural biology, and enzymology. In his free time he enjoys running, hiking, reading, and visiting family and friends.
Rob Magin is originally from Silver Spring, MD. He obtained his BA in biology from Northwestern University in 2012 and his PhD from the University of Pennsylvania in biochemistry and molecular biophysics in 2017. He joined the Buhrlage lab as a postdoctoral research fellow in the Fall of 2017. His research interests include chemical biology, structural biology, and enzymology. In his free time he enjoys running, hiking, reading, and visiting family and friends.
Bin Hu, PhD
Bin is originally from China and received his BS and MS degree in Medicinal Chemistry at China Pharmaceutical University. After that, He moved to the US and received his PhD in Organic Chemistry from Brandeis University in 2018, then joined the Buhrlage lab as a postdoctoral research fellow in the Fall of 2018. His research interests include organocatalysis, asymmetric synthesis and medicinal chemistry. In his spare time, he enjoys playing and watching basketball, running, and spending time with his family.
Bin is originally from China and received his BS and MS degree in Medicinal Chemistry at China Pharmaceutical University. After that, He moved to the US and received his PhD in Organic Chemistry from Brandeis University in 2018, then joined the Buhrlage lab as a postdoctoral research fellow in the Fall of 2018. His research interests include organocatalysis, asymmetric synthesis and medicinal chemistry. In his spare time, he enjoys playing and watching basketball, running, and spending time with his family.
Graduate Students
Laura Doherty
Laura grew up in Winston-Salem, North Carolina and graduated from the University of North Carolina Chapel Hill with a degree in chemistry and biology in 2015. She is currently a PhD candidate in Harvard University's Chemical Biology program with the goal of better understanding cancer biology and therapeutic targets. in her free time she enjoys reading, painting and spending time with friends.
Laura grew up in Winston-Salem, North Carolina and graduated from the University of North Carolina Chapel Hill with a degree in chemistry and biology in 2015. She is currently a PhD candidate in Harvard University's Chemical Biology program with the goal of better understanding cancer biology and therapeutic targets. in her free time she enjoys reading, painting and spending time with friends.
Anthony Varca
Anthony is a graduate student in the Harvard Chemical Biology PhD program. He grew up in Wethersfield, CT and received his B.S. in Chemistry from Northeastern University. After graduating, he spent 3 years as a research technician in Dr. James Bradner's lab at DFCI doing medicinal chemistry prior to graduate school. His research interests include the development of small molecule probe compounds for studying DUBs' role in disease and function. In his spare time, Anthony enjoys playing and watching soccer, going camping and cooking/baking.
Anthony is a graduate student in the Harvard Chemical Biology PhD program. He grew up in Wethersfield, CT and received his B.S. in Chemistry from Northeastern University. After graduating, he spent 3 years as a research technician in Dr. James Bradner's lab at DFCI doing medicinal chemistry prior to graduate school. His research interests include the development of small molecule probe compounds for studying DUBs' role in disease and function. In his spare time, Anthony enjoys playing and watching soccer, going camping and cooking/baking.
Wai Cheung (Adrian) Chan
Officially British, Adrian grew up in Hong Kong and spent part of his adolescence in the Netherlands. He graduated from Amherst College with a degree in Chemistry and English in 2017, and is currently a PhD candidate in Harvard University's Chemical Biology program. He is a joint student with the Marto lab, also at the DFCI. Adrian is interested in applying mass spectrometry chemoproteomics to DUB inhibitor discovery/development. In his free time, he enjoys cooking, sewing, and exploring Boston.
Officially British, Adrian grew up in Hong Kong and spent part of his adolescence in the Netherlands. He graduated from Amherst College with a degree in Chemistry and English in 2017, and is currently a PhD candidate in Harvard University's Chemical Biology program. He is a joint student with the Marto lab, also at the DFCI. Adrian is interested in applying mass spectrometry chemoproteomics to DUB inhibitor discovery/development. In his free time, he enjoys cooking, sewing, and exploring Boston.
Alex Felix
Alex is currently a student in the Harvard Chemistry and Chemical Biology PhD program. She grew up in Gustine, California and obtained her B.S. in Chemistry with biological concentration from Stanford University in 2018. Her research interests include chemical biology, synthesis, and medicinal chemistry. During her spare time, Alex enjoys reading and writing fiction, as well as traveling to new places.
Alex is currently a student in the Harvard Chemistry and Chemical Biology PhD program. She grew up in Gustine, California and obtained her B.S. in Chemistry with biological concentration from Stanford University in 2018. Her research interests include chemical biology, synthesis, and medicinal chemistry. During her spare time, Alex enjoys reading and writing fiction, as well as traveling to new places.
Laboratory Technician
Former Members
Ilaria Lamberto, PhD
Nathan Schauer, PhD
Rebekka Roberts
Wanyi Hu
Tatiana Mikhailova
Chinmay Bakshi
Sumner Perera
Ethan DaSilva
Isabella Jaen Maisonet
Mathiu E. Perez Rodriguez
Tatiana Mikhailova
Chinmay Bakshi
Sumner Perera
Ethan DaSilva
Isabella Jaen Maisonet
Mathiu E. Perez Rodriguez