Welcome to the Buhrlage Lab
Dysregulation of protein homeostasis drives many types of cancer, infection and neurodegeneration. The ubiquitin system performs a central role in maintenance of proteostasis through reversible post-translational addition of (poly)ubiquitin to proteins, a mark that: 1) tags substrates for destruction by the proteasome or lysosome and 2) functions as a switch for gene expression through ubiquitylation of histone lysine sidechains. Ubiquitylation is coordinated by the action of ubiquitin activating, conjugating, ligating (E1, E2, E3) and deubiquitylating enzymes (DUBs). The mission of our group is to develop first-in-class inhibitors and prototype drugs for DUBs that can be utilized to pharmacologically validate members of the gene family as new targets for cancer treatment and other diseases.